Immunology

Immunology

  • Print

Viracor Eurofins has a rich history spanning more than 27 years of proven leadership in immunology research and clinical diagnostic testing.  Our comprehensive testing menu addresses the clinician’s need to assess  immune system function in these situations:

  • Bone marrow and solid organ transplantation
  • Primary immune deficiency
  • Acquired immune deficiency syndrome
  • Autoimmune diseases
  • Hypersensitivity
  • Vaccine efficacy

Viracor Eurofins offers a number of novel tests to evaluate the innate and adaptive immune system.  Our exclusive Pneumococcal Avidity test, for example, provides the clinician with specific information about the patient's B cell function by assessing the avidity of a patient's pneumococcal antibody response in conjunction with the pneumococcal antibody concentration. Viracor Eurofins' cutting-edge Mannan-Binding Lectin (MBL) Pathway testing service employs a series of tests to identify innate immune system deficiencies which can predispose patients to serious and recurring infections.

In the area of transplant medicine, Viracor Eurofins' extensive menu of assays assists clinicians in diagnosing, treating and monitoring the most critical patient cases during acute conditions such as graft versus host disease (GVHD). Monitoring inflammatory cytokines during the pre-transplant conditioning phase may provide an indication of GVHD and other adverse conditions following hematopoietic stem cell transplant (HSCT)1,2,4,5. Post-transplant, studies have demonstrated the link between elevated cytokine levels and transplant related complications such acute GVHD.1,2,3,5

 

Pre-Transplant

Post-Transplant - Acute GVHD

Assay

Phase 1 – Conditioning

Phase 2 - Induction & Expression

Phase 3 - Effector

Immunology

TNFα, IL-1, IL-6, IFNγ

T-cell Receptor Excision Circle (TREC)

IL-2, IL-6, IFNγ

 

TNFα, IL-1, IL-6

T-cell Receptor Excision Circle (TREC)

 

 Immunology Test Menu

Classification Test
Preliminary Immune Status Check      IgG Subclasses
Immunoglobulin E (IgE)
Immunoglobulin A (IgA)
Immunoglobulin G (IgG)
Immunoglobulin M (IgM)
 Vaccine Antibody Response     Diphtheria Antibody
Tetanus Antibody
Haemophilus influenza b Antibody
Pneumococcal Antibody
Pneumococcal Antibody Avidity
 T cell Development and Function    T Cell Fx™ Select
T Cell Fx™ Complete
ImmuKnow®
T-cell Receptor Excision Circle (TREC) Test
 Autoantibodies     Anti-IgA
Anti-IgE
CU Index™
Anti-Thyroid Peroxidase IgG
Anti-Thyroglobulin IgG
Complement Assessment     MBL Protein
MBL Pathway Function
C1 Esterase Inhibitor Functional
C1 Esterase Inhibitor Protein
C1q Complement
Innate Immunity Development and Function   Oxidative Burst
TLR Function
 Angioedema    C1 Esterase Inhibitor Functional
C1 Esterase Inhibitor Protein
C1q Complement
C4
Inflammatory Markers                  GM-CSF
Interferon-gamma
Interleukin-10
Interleukin-12p70
Interleukin-13
Interleukin-1 beta
Interleukin-2
Interleukin-4
Interleukin-5
Interleukin-6
Interleukin-8
TNF-alpha
Eotaxin-3
Soluble IL-2 Receptor Alpha
Eosinophil Cationic Protein
Eosinophil Derived Neurotoxin

To learn more about the specific tests we offer, search under the Immunology specialty in the Test Menu.

References

1.     Ferrara et al. (2003). The pathophysiology of acute graft-versus-host disease. International Journal of Hematology, 78: 181-187

2.     Goker et al. (2001). Acute graft-vs-host disease: Pathobiology and management. Experimental Hematology. 29: 259-277

3.     Liu et al. (2010). Diarrhea during the conditioning regimen is correlated with the occurrence of severe acute graft-versus-host disease through systemic release of inflammatory cytokines. Biol Blood Marrow Transplant, 16: 1567-1575

4.     Min et al. (2001). Cytokines –The kinetics of circulating cytokines including IL-6, TNF-α, IL-8 and IL-10 following allogeneic hematopoietic  stem cell transplantation. Bone Marrow Transplantation, 28: 935-940

5.     Reddy & Ferrara. (2003). Immunobiology of acute graft-versus-host disease. Blood Review, 17: 187-194