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Immunoglobulin A (IgA) Low Range

Test Code: 6
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Clinical Utility

For the evaluation of patients with recurrent infection for the possibility of IgA deficiency(IgAD). Patients with IgA deficiency may develop antibodies against IgA that make them susceptible to adverse reactions to blood products including intravenous immunoglobulin. IgAD has also been reported to progress to Common Variable Immunodeficiency (CVID).

Procedure

Radial immunodiffusion using calibrators referenced to CRM470. The performance characteristics of this test were determined by Viracor Eurofins. This test has not been cleared or approved for diagnostic use by the U.S. Food and Drug Administration.

8 business days from receipt of specimen

Specimen Type Order Code CPT Code NY Approved Volume Assay Range Special Instructions
serum 6 82784 Yes

1 mL (min. 200 uL)

Reported in mg/dL. IgA deficiency is indicated if IgA level is < 5 mg/dL for adults. The lower limit of quantitation is 0.1 mg/dL.

  • Collect 1 mL, no special shipping requirements.
  • Stability 7 days ambient, 2 weeks refrigerated, >2 weeks frozen.
Causes for Rejection

Lipemic samples may lead to rejection

Specimens are approved for testing in New York only when indicated in the Specimen Information field above.

The CPT codes provided are based on Viracor Eurofins' interpretation of the American Medical Association's Current Procedural Terminology (CPT) codes and are provided for general informational purposes only. CPT coding is the sole responsibility of the billing party. Questions regarding coding should be addressed to your local Medicare carrier. Viracor Eurofins assumes no responsibility for billing errors due to reliance on the CPT codes illustrated in this material.

References

Hammarstrom L, Vorechovsky I, Webster D. Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID). Clin Exp Immunol. 2000; 120:225-231.

Burrows D, Cooper MD: IgA Deficiency. Adv Immunol 1997; 65:245-276.

Aghamohammadi A, Mohammadi J, Parvaneh N, Rezael N, Moin M, Espanol T. and Hammarstrom L. Progression of Selective IgA Deficiency to   Common Variable Immunodeficiency. Int Arch Allergy Immunol 2008;147:87-92.

Horn J, Thon V, Bartonkova D, Salzer U, warnatz K, Schlesier M, Peter H, and Grimbacher B. Anti-IgA antibodies in Common Variable Immunodeficeny

(CVID): Diagnostic workup and therapeutic strategy.  Clin Immunol 2007;122:156-162.

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