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CSF NGS for Bacterial Identification

This assay detects and taxonomically characterizes the etiological agents of bacterial meningitis. For immunocompromised patients, broad-range next generation sequencing (NGS) of CSF can be successfully leveraged to aid in an accurate and timely diagnosis, support treatment decisions and could reduce the patient’s hospital stay and overall cost of care.

Utilization Benefits

  • Get definitive results in difficult-to-diagnose immunocompromised patients within 3 days from specimen receipt
  • Identify the causative bacteria from a broad range of targets, including culture-negative infections and other uncommon etiologic agents
  • Rule out suspected Bacterial Meningitis with a “Not Detected” result
  • Administer antibiotics without the risk of cultures' false-negatives
  • Administer the right treatment based on the patient's pathogenic 16S report

How It Works: CSF Specimen Processing

With results in 3 business days from receipt of specimen, the 16S NGS Bacterial Meningitis test can help you get results faster, when it matters most.

16S, Pathogens Not Detected

16S NGS, Pathogens Detected

Pathogenic Bacterial Targets

The 16S NGS Bacterial Meningitis assay is validated to detect and identify the most common bacterial pathogens associated with meningitis:

– Streptococcus pneumoniae
– Neisseria meningitidis
– Haemophilus influenzae
– Listeria monocytogenes
– Streptococcus agalactiae (Group B Strep)
– Escherichia coli
– Plus many other less common bacterial pathogens that are of concern in the immunocompromised patient population
16S NGS Bacterial Meningitis

Cost of Care

"Delayed diagnosis may lead to inappropriate treatment, more severe complications, and prolonged hospital stays."

An accurate diagnosis of bacterial meningitis aids in promoting antimicrobial stewardship, reducing the patient’s hospital stay and overall cost of care. According to, “Cost of managing meningitis and encephalitis among adult patients in the United States of America,” published in the International Journal of Infectious Diseases, the data suggest that the total cost for meningitis is related to the time of diagnosis, stay in the intensive care unit and etiological agent.

Source: J.M. Balada-Llasat et. al. September 20, 2017. Cost of managing meningitis and encephalitis among adult patients in the United States of America. International Journal of Infectious Diseases, 71:117-121.

Cost of Care 16S NGS Bacterial Meningitis

Related Meningitis Testing for CSF Specimen Types

See our Specimen Grid or search the test menu for more CSF specimen type options

Test Name Test Code CPT Code(s) Turnaround Time
16S NGS Bacterial Meningitis 403575P 87800, 81479

3 business days from receipt of specimen

Aspergillus Galactomannan EIA 1603 87305

Same day (within 8-12 hours from receipt of specimen), Monday through Saturday.


Fungitell® β-D-Glucan 1703 87449
Herpes Simplex Virus 1 & 2 Quantitative Real-time PCR 8503 87530
Varicella Zoster Virus Quantitative Real-time PCR 9503 87799
Enterovirus Quantitative Real-time RT-PCR 1403 87799
Cytomegalovirus Quantitative Real-time PCR 5503 87799
HHV-6 Quantitative Real-time PCR 6503 87533

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