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Histamine Plasma

Test Code: 1136
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Clinical Utility

Histamine measurements are often useful in evaluating patients with suspected anaphylaxis, mastocystosis, gastrointestinal disease, reactions to radiocontrast media, and drug induced anaphlactoid reactions. Additional information may also be obtained by measuring the concentration of tryptase, a mast cell enzyme. Unlike histamine, tryptase is not found in basophils.


Enzyme Immunoassay (monoclonal-based competitive binding EIA) after chemical derivatization by acylation (See McBride reference). This test has not been cleared or approved for diagnostic use by the U.S. Food and Drug Administration.

2-3 business days from receipt of specimen

Specimen Type Order Code CPT Code NY Approved Volume Assay Range Special Instructions
plasma 1136 83088 Yes

1 mL (min. 250 uL)

<1.0 mg/dL

  • Sample preparation is critical: Collect 3 mL of blood in an EDTA tube (lavender top).
  • Cool immediately on ice.
  • Centrifuge at 900 x g for 10 minutes at 4° C. The centrifugation should be performed within 20 minutes of collection
  • Carefully remove 1 mL of plasma from the upper part of the tube and transfer to a plastic vial and freeze.
  • Ship frozen overnight on dry ice. Not stable ambient or refrigerated.

Specimens are approved for testing in New York only when indicated in the Specimen Information field above.

The CPT codes provided are based on Viracor Eurofins' interpretation of the American Medical Association's Current Procedural Terminology (CPT) codes and are provided for general informational purposes only. CPT coding is the sole responsibility of the billing party. Questions regarding coding should be addressed to your local Medicare carrier. Viracor Eurofins assumes no responsibility for billing errors due to reliance on the CPT codes illustrated in this material.


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