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Transforming Growth Factor beta 1 (TGF ß-1)

Test Code: 30244
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Clinical Utility

This is a quantitative EIA assay for the human cytokine Transforming Growth Factor beta 1 ( TGF ß-1). TGF β-1 plays a role in tissue regulation and is used as an aid to determine underlying causes of unusual or inflammatory disorders. TGF β-1 is a pleotropic cytokine that possesses both inflammatory and immune-suppressive characteristics. It is a secreted protein that performs many cellular functions, including control of cell growth, proliferation, differentiation and apoptosis.

Procedure

Multiplex array format with Meso Scale Discovery (MSD®) Sector Imager 2400. MSD Cytokine assays measure from one to ten cytokines in a 96 well MULTI-SPOT plate. The assay employs a sandwich immunoassay format. MSD technology uses electrochemiluminescence detection; a CCD camera allows for the quantification of light emitted from each spot in each well. MSD software generates a standard curve to determine sample cytokine concentrations. This test has not been cleared or approved for diagnostic use by the U.S. Food and Drug Administration.

Specificity

Specific for TGF ß-1 and does not cross-react with TGF ß-2 and TGF ß-3.

3-5 business days from receipt of specimen

Specimen Type Order Code CPT Code NY Approved Volume Assay Range Special Instructions
plasma 30244 83520 No

2 mL (0.2 mL)

867-6662 pg/mL

  • EDTA platelet poor plasma. Within 30 minutes of collection, centrifuge at 1,000 X g for 15 min. Pull off the plasma to a clean centrifuge tube.
  • Second centrifugation is at 3,000 X g for 10 min. Pull off plasma to clean transport tube.
  • Sample should be frozen and stored at -70oC or below until shipped. Ship on dry ice by overnight priority.
Shipping

Ship Monday through Friday. Friday shipments must be labeled for Saturday delivery. All specimens must be labeled with patient's name and collection date. A Viracor Eurofins test requisition form must accompany each specimen. Multiple tests can be run on one specimen. Ship specimens FedEx Priority Overnight® to: Viracor Eurofins, 1001 NW Technology Dr, Lee's Summit, MO 64086.

Causes for Rejection

Grossly lipemic samples.

Specimens are approved for testing in New York only when indicated in the Specimen Information field above. The CPT codes provided are based on Viracor Eurofins' interpretation of the American Medical Association's Current Procedural Terminology (CPT) codes and are provided for informational purposes only. CPT coding is the sole responsibility of the billing party. Questions regarding coding should be addressed to your local Medicare carrier. Viracor Eurofins assumes no responsibility for billing errors due to reliance on the CPT codes illustrated in this material.

References

Information derived from MSD Human TGF-ß-1 Kit; Meso Scale Diagnostics, LLC.

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